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While one might think adding a GLP-1 agonist would help, the primary effect of high-dose agonists is usually a further slowing of the upper GI tract

Moreover, following ACMG guidelines (Richards et al., 2015) a large proportion of variants can be classified as of uncertain significance (VUS) or benign, without considering their additive burden in shaping polygenic phenotypes

Preclinical research has explored its potential role in tissue repair, tendon and ligament models, gut integrity, inflammation modulation and blood vessel formation